Enpp-1-IN-12 (C09-1130-734)

Enpp-1-IN-12 (compound 43) is a potent and orally active ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor, with a Ki of 41 nM. Enpp-1-IN-12 exhibits anti-tumor activityIn VitroEnpp-1-IN-12 (5 μM) exhibits half-life and intrinsic clearance of >120 min and <11.55 μL/min/million cells and 61.88 min and 22.4 μL/min/million cells in human and mouse hepatocytes, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoEnpp-1-IN-12 (100 mg/kg; p.o.) inhibits tumor growth in LLC1 syngeneic murine tumor model for lung cancer . Enpp-1-IN-12 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (F=45.1%), half-life (t 1/2 =1.04 h), and C max (303.10 ng/mL) in healthy female BALB/c mice . Enpp-1-IN-12 (1 mg/kg; i.v.) exhibits half-life (t 1/2 =0.76 h), C max (308.64 ng/mL), and CL of 73.22 mL/min/kg in healthy female BALB/c mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Ki: 41 nM (ENPP1). Specification: 0.99 Molecular Formula: C16H18N6O3S Molecular Weight: 374.42