Enpp-1-IN-14 (Compound 015) is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC 50 value of 32.38 nM for recombinant human ENPP-1 . Enpp-1-IN-14 has anti-tumor activityIn VivoEnpp-1-IN-14 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×10 5 MC38 cells) Dosage: 50 mg/kg Administration: IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site) Result: Significantly inhibited tumor growth.Form:SolidIC50& Target:IC 50 : 32.38 nM (recombinant human ENPP-1). Specification: 0.99 Molecular Formula: C15H22ClN5O4S Molecular Weight: 403.88
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- E649281-50mg
- CAS:
- 2687222-59-7
- Product Size:
- 50mg
