ENVIROXIME (C005B-309748)

Catalog No.: C005B-309748
Mfr. No.: SML2995-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: EA

Price: $999.17

List Price: $1,110.19

Biochem/physiol Actions Enviroxime (LY 122772) is a selective phosphatidylinositol 4-kinase type IIIβ: (PI4KB, PI4KIIIβ:) inhibitor (IC50 = 60 nM/PI4KB vs. 1.

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Description
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Biochem/physiol Actions

Enviroxime (LY 122772) is a selective phosphatidylinositol 4-kinase type IIIβ (PI4KB, PI4KIIIβ) inhibitor (IC50 = 60 nM/PI4KB vs. 1.917 µM/PI4KA) with antiviral potency against enteroviruses, including rhinovirus (RV plaque reduction IC50 ≤40 ng/mL; HeLa), poliovirus (PV), coxsackievirus (CV). PI4KB is a host factor essential for enterovirus replication, mutations in viral 3A protein that recruits PI4KB to the replication sites result in enviroxime resistance. Enviroxime is also reported to impede PI4K-independent hepatitis C (HCV) replication at least partially by an inhibitory effect on PI3Ks.

UPC:: 51342102
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML2995-25MG
CAS:: 72301-79-2

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