(-)-Epicatechin (C09-0869-597)

Epicatechin is a flavanol. Cacao products are rich in epicatechin. Epicatechin enhances the skeletal muscle structure in heart failure patients and minimises the cardiometabolic risks. It can be used for treating sarcopenia. Epicatechin reduces myostatin and β-galactosidase and increases the level of markers of muscle growth.Antioxidant found in chocolate.Product description：(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.Application：(−)-Epicatechin (EC) has been used:as an antioxidant to downregulate nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase and improve insulin sensitivity in in vivo (high fat-fed mice) and in vitro (HepG2 cells) studiesto study its effect on blood pressure, nitric oxide synthase (NOS) activity and anxiety-like behavior on borderline hypertensive rat (BHR) modelsto test its effect on neuronal survival in the hippocampus of middle-aged rats on swimming training, under oxidative stressto study its antioxidant activity in dark chocolateas a characteristic compound in polyphenols analysis. Specification: ≥97% (HPLC) MDL Number: MFCD00075648 Molecular Formula: C15H14O6 Molecular Weight: 290.27 EC Number: 207-710-1 PubChem CID: 72276 Isomeric SMILES: C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O Beilstein Registry Number: 92760 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/E130023-SCI_ee4741f8e333a33e875a14f5b749be10.pdf