General description
Erastin is a cell-permeable piperazinyl-quinazolinone. It interacts with antiporter system Xc-.
Application
Erastin has been used:
- as a positive control for inducing ferroptosis in hepatic stellate cell (HSC)
- to induce ferroptosis and in transferrin internalization assay of human fibrosarcoma HT1080 cells
- to induce ferroptosis of muscle-derived cell lines
Biochem/physiol Actions
Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces ferroptosis, a non-apoptotic tumor cell death, by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death.
Features and Benefits
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- UPC:
- 51112004
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- E7781-1MG