Etoposide (C007B-144551)

Etoposide is an antitumor agent that complexes with topoisomerase II and DNA to enhance double-strand and single-strand cleavage of DNA and reversibly inhibit religation. Blocks the cell cycle in in S-phase and G2-phase of the cell cycle; induces apoptosis in normal and tumor cell lines; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that overexpress Mdm2.Inhibits DNA synthesis via topoisomerase II inhibitionproduct description：Etoposide is synthesised from podophyllotoxins of plants. Specification: 0.98 MDL Number: MFCD00869325 Molecular Formula: C29H32O13 Molecular Weight: 588.56 EC Number: 251-509-1 PubChem CID: 36462 Isomeric SMILES: C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/E121713-SCI_978a30051259704c1df05d263080d568.pdf