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ETOPOSIDE 1PC X 25MG

Sigma Aldrich

Catalog No.
C15-1232-396
Manufacturer No.
341205-25MG
Manufacturer Name
Sigma-Aldrich
Quantity
25
Unit of Measure
MG
Price: $194.64
List Price: $216.27

A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC 50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma.

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General description

A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.

A cell-permeable, topoisomerase II inhibitor (IC50 = 59.2 µM). A derivative of podophyllotoxin (Cat. No. 540040) that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
topoisomerase 2

Product does not compete with ATP.

Reversible: no

Target IC50: 59.2 µM inhibiting topoisomerase II

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

De Lange, A.M., et al. 1995. J. Virol. 69, 2082.
Kaufman, S.H., et al. 1993. Cancer Res.53, 3976.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta1175, 147.
Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991. J. Clin. Oncol.9, 70.
Einhorn, L.H., et al. 1988. J. Clin. Oncol.6, 451.
Issel, B.F. 1982. Cancer Chemother. Pharmacol.7, 73.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:
51111739
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
341205-25MG

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