InformationEtravirine (TMC125) Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor ( NNRTI ) used for the treatment of HIV.In vitroEtravirine (TMC125), is highly active against wild-type HIV-1 with EC50 of 1.4 nM to 4.8 nM and shows some activity against HIV-2 with EC50 of 3.5 μM. TMC125 also inhibits a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus.In vivoEtravirine has a high genetic barrier to the development of resistance. In phase IIb trials in treatment-experienced patients, including those infected with virus resistant to NNRTIs and protease inhibitors (PIs), TMC125 is active against HIV resistant to currently available NNRTIs, with a similar tolerability profile to that of the control group.Cell Datacell lines：Concentrations：Incubation Time：Powder Purity:≥95%. Specification: 10mM in DMSO Molecular Formula: C20H15BrN6O Molecular Weight: 435.28
- UPC:
- 51343704
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.85 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- E408338-1ml
- CAS:
- 269055-15-4
- Product Size:
- 1ml
