EW-7197-1 mg

Thomas Scientific

Catalog No.: C08-0327-498
Manufacturer No.: 19231-1
Manufacturer Name: Cayman Chemical Company
Quantity: 1
Unit of Measure: EA

Price: $267.29

List Price: $296.99

EW-7197 is a potent inhibitor of activin receptor-like kinase 5 (ALK5, also known as TGF-&beta receptor type 1 IC50 = 12.9 nM).

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Description
Specifications

EW-7197 is a potent inhibitor of activin receptor-like kinase 5 (ALK5, also known as TGF-β receptor type 1; IC₅₀ = 12.9 nM). It also inhibits ALK2 and ALK4 at nanomolar concentrations. EW-7197 blocks TGF-β/Smad signaling, cell migration, invasion, and lung metastasis in mouse mammary tumor virus/c-Neu mice and 4TI orthotopic-grafted mice. It also inhibits epithelial-to-mesenchymal transition (EMT) in TGF-β-treated breast cancer cells.2 EW-7197 is used to block TGF-β signaling and EMT in animal models of cancer and fibrosis.

UPC:: 12350000
Condition:: New
Availability:: 3 Days
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: 19231-1

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