F 13714 fumarate (C09-1133-920)

F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stressIn VitroF13714 targets 5-HT1A autoreceptors. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoIn UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels . F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5% . F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement . F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in naïve rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:5-HT 1A Receptor. Specification: 0.98 Molecular Formula: C25H29ClF2N4O5 Molecular Weight: 538.97