F13714 (C005B-308868)

Catalog No.: C005B-308868
Mfr. No.: SML3509-50MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: EA

Price: $1,536.17

List Price: $1,706.86

Biochem/physiol Actions F13714 is an orally active, high-affinity, potent, biased serotonin receptor 5-HT1A agonist (pKi = 10.12 against 0.

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Description
Specifications

Biochem/physiol Actions

F13714 is an orally active, high-affinity, potent, biased serotonin receptor 5-HT1A agonist (pKi = 10.12 against 0.2 nM (±)-8-OH-DPAT binding to rat cortex tissue). F13714 inhibits 100 μM forskolin-induced cAMP accumulation in human 5-HT1A-expressing HeLa cells (pIC50 = 8.67) and displays antidepressant efficacy in vivo (ED50 = 0.05 mg/kg p.o., Emax >80%; rat forced swimming). F13714 and F15599 display differential biased agonism and, when administerd in vivo, F13714 preferentially activates raphe-located autoreceptors, while F15599 preferentially activates post-synaptic heteroreceptors.

UPC:: 51182109
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3509-50MG
CAS:: 208109-38-0

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