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FERROSTATIN-1 (C005B-313195)

Catalog No.
C005B-313195
Mfr. No.
SML0583-5MG
Mfr. Name
Sigma-Aldrich
Qty/UOM
5
UOM
MG
Price: $192.20
List Price: $213.56

Application Ferrostatin-1 has been used to determine its inhibitory effect on the cell death profiles. Biochem/physiol Actions Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis.

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Application

Ferrostatin-1 has been used to determine its inhibitory effect on the cell death profiles.

Biochem/physiol Actions

Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin-1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS.

Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.

UPC:
51192443
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
SML0583-5MG
CAS:
347174-05-4

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