FIBROBLAST GROWTH FACTOR -16 HUMAN

General description

Fibroblast growth factor-16 (FGF-16) is a heparin binding growth factor that is a member of the FGF9 subfamily. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. Recombinant human FGF-16 is a 23.7 kDa protein consisting of 207 amino acid residues.

Biochem/physiol Actions

Fibroblast growth factor-16 (FGF-16) signals through FGFR 2c and 3c. FGF-16 plays a role in the development of the central nervous system. This protein has a positive effect on mitosis and cell survival. FGF-16 also has roles in tissue repair, embryonic development, morphogenesis and tumor growth.

Sequence

MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH QKFTHFLPRP VDPSKLPSMS RDLFHYR

Physical form

Lyophilized from 5 mM sodium phosphate, pH 9.0, containing 0.1 M L-arginine and 0.4 mM DTT.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.