InformationFisogatinib (BLU-554) Fisogatinib (BLU-554) is a potent, highly-selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50s for FGFR1-3 is 624-2203 nM.TargetsFGFR4 (Cell-free assay) 5 nMIn vitroBLU-554 exploits a unique interaction with FGFR4 to confer potency and selectivityIn vivoBLU-554 is well tolerated in these tumor models. Administration of BLU-554 induces tumor regression in liver cancer models. Specification: 0.98 Molecular Formula: C24H24Cl2N4O4 Molecular Weight: 503.38 PubChem CID: 91885617 Isomeric SMILES: COC1=CC(=C(C(=C1Cl)C2=CC3=CN=C(N=C3C=C2)N[C@@H]4COCC[C@@H]4NC(=O)C=C)Cl)OC Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/F414033-SCI_4080a8da75689e692dfe296c4fedbb44.pdf
- UPC:
- 12352208
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.97 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- F414033-100mg
- CAS:
- 1707289-21-1
- Product Size:
- 100mg
- Hazard Statement Codes:
- H315:H319:H335
- Precautionary Statement Codes:
- P261:P305+P351+P338
