General description
FLT1 (fms-related tyrosine kinase 1) or VEGFR (vascular endothelial growth factor receptor) is one of the receptor tyrosine kinase, which acts as a receptor for VEGF. VEGF is a predominant angiogenesis stimulating factor. FLT1 is a transmembrane receptor. Soluble FLT1 (sFLT1) is an alternatively spliced soluble form of FLT1, expressed by multiple tissues. It acts as a negative regulator of VEGF. It does not contain the cytosolic and transmembrane domains.
Biochem/physiol Actions
FLT1 (fms-related tyrosine kinase 1) or VEGFR (vascular endothelial growth factor receptor) is implicated in angiogenesis in tumors, which plays a key role in tumorigenesis, invasion and metastasis of tumors, especially the malignant ones. In human circulation, angiogenesis is balanced by soluble FLT1 (sFLT1) and VEGF. An imbalance leads to multiple conditions such as pre-eclampsia. sFLT1 plays an essential role in the angiogenesis of placenta. An overexpression of this protein in placenta is associated with prenatal arsenic exposure and thus, reduced birth weight.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC
- UPC:
- 41116010
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- F6307-10UG
