Flutamide (C09-0895-912)

InformationFlutamide Flutamide (SCH-13521) is an antiandrogen drug, with its active metablolite binding at androgen receptor with K i values of 55 nM, and primarily used to treat prostate cancer.In vitroFlutamide (Eulexin) is an antiandrogen drug. Flutamide-OH, the active metabolite of flutamide, directly binds at rat anterior pituitary androgen receptor with Ki values of 55 nM. Flutamide does not affect the proliferation of an androgen-sensitive clone of the mouse mammary carcinoma Shionogi SC-l 15 cells in culture, shows only antiandrogenic effect, but not androgenic effect. Flutamide provides treatment for prostate cancer when used along with leuprolide.In vivoFlutamide causes a markedly reduction in rat ventral prostate weight from 319 mg to 245 mg. A combination of flutamide and LHRH agonist induces an additive effect with a decrease in prostate weight to 101 mg, and an marked drop in prostatic ODC activity.Cell Datacell lines：Concentrations：~1 μMIncubation Time：40 daysPowder Purity:≥99%. Specification: 10mM in DMSO Molecular Formula: C11H11F3N2O3 Molecular Weight: 276.21