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fmoc-gly-(dmb)gly-oh 1 g

FMOC-GLY-(DMB)GLY-OH 1 G

Sigma Aldrich

Catalog No.
C15-1284-664
Manufacturer No.
8521090001
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
GR
Price: $549.46
List Price: $845.32

The use of this derivative was found to be essential for the synthesis of peptides related to nucleolin [1] . Fmoc-Aaa-(Dmb)Gly-OH dipeptides offer the same benefits as pseudoproline dipeptides in Fmoc SPPS but for peptide sequences containing Gly.

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General description

The use of this derivative was found to be essential for the synthesis of peptides related to nucleolin [1]. Fmoc-Aaa-(Dmb)Gly-OH dipeptides offer the same benefits as pseudoproline dipeptides in Fmoc SPPS but for peptide sequences containing Gly. They are extremely easy to use. Standard coupling methods like PyBOP®/DIPEA or DIPCDI/HOBt can be used for their introduction. Removal of the Dmb group and regeneration of the glycine residue occurs during the course of standard TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Literature references

[1] S. Zahariev, et al. (2005) J. Pept. Sci., 11, 17.

Linkage

Replaces: 04-12-1266

Analysis Note

Color (visual): white to slight yellow
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 2.00 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:
12352202
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
8521090001

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