General description
Building block [1] for the introduction by Fmoc SPPS of the hydrolytically stable phosphotyrosine analog phosphonodifluoromethylphenylalanine (F2Pmp) [2]. The pKa of F2Pmp more closely resembles that of a phosphate group making it better analog than phosphonomethylphenylalanine.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS
Literature references
[1] M. F. Gordeev, et al. (1994) Tetrahedron Lett., 35, 7585.
[2] T. R. Burke, Jr. (2006) Curr. Top. Med. Chem., 6, 1465.
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 90.0 % (a/a)
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.1 %
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51442005
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 8522888250