General description
Introduction of 4-sulfo-phenylalanine is an effective strategy for increasing solubility of a peptide. This amino acid has also been employed in analogs of angiotensin 2 [1], phytosulfokine [2], and cyclolinopeptide A [3]. Its incorporation during solid phase synthesis using Fmoc-Phe(SO3Na)-OH is best carried out with base-mediated coupling methods such as PyBOP® or HBTU.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references
[1] E. Escher, et al. (1983) , 66, 1355.
[2] A. Bahyrycz, et al. (2004) , 10, 462.
[3] Y. Fujiwara, et al. (1994) , 42, 724.
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in DMF): -17.0 - -15.0 °
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Purity TLC (BAW 1): ≥ 97.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 489.47. Empirical Formula: C24H20NNaO7S. Quality Level: 200. product line: Novabiochem®. . form: powder. reaction suitability: reaction type: Fmoc solid-phase peptide synthesis. manufacturer/tradename: Novabiochem®. . application(s): peptide synthesis. functional group: sulfonic acid. storage temp.: 15-25°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 12142207
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 8523780001