Application
Folic acid has been used:
- to induce acute kidney injury in mice
- as a supplement to cultivate MCF-7 breast cancer cells.
- to construct folate or TNF-related apoptosis-including ligand (TRAIL)-conjugated nanomicelles
Biochem/physiol Actions
Enzyme cofactor essential for the synthesis, methylation, and repair of DNA. Folic acid supplements may reduce colorectal cancer risk.
Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).
- UPC:
- 51191918
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- F7876-1G