FORMYL PEPTIDE RECEPTOR-LIKE 1 ANTAGONIST WRW4 - CALBIOCHEM (C005B-227403)

General description

A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with ligand-receptor interaction {IC₅₀ = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks ligand-mediated [Ca²⁺]_i increase, ERK activation, and chemotactic migration of FPRL1-expressing RBL-2H3 cells at a concentration of 10 µM. Also inhibits Aβ₄₂ peptide-induced superoxide generation and prevents its internalization in human macrophages.

A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC₅₀ = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca²⁺]_i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Aβ₄₂ peptide-induced superoxide generation and prevents its internalization in human macrophages.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Formyl Peptide Receptor-Like 1 (FPRL1)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 230 nM for FPRL1 Agonist

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

H-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Bae, Y.S., et al. 2004. J. Immunol.173, 607.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 1104.27. Empirical Formula: C₆₁H₆₅N₁₅O₆. Quality Level: 100. Assay: ≥. 95% (HPLC). form: lyophilized solid. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, desiccated (hygroscopic). color: white. solubility: DMSO: 5 . mg/mL. shipped in: ambient. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

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