FR 167653 (C09-1133-772)

FR 167653 (FR 167653 sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivoIn VivoFR 167653 (FR 167653 sulfate) (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Inbred male Balbuc mice (aged 8 weeks) Dosage: 32 kg/mg Administration: Subcutaneous injection; 24-48 hours Result: The scores of acute tubular necrosis in FR-167653-treated mice were significantly lower in vehicle-treated mice at 24 and 48 h after ischaemiaureperfusion both in cortex and outer medulla.Form:SolidIC50& Target:p38 MAPK. Specification: 0.99 Molecular Formula: C24H20FN5O6S Molecular Weight: 525.51 PubChem CID: 135484078 Isomeric SMILES: C1CN(NC2=C(C(=NN21)C3=CC=C(C=C3)F)C4=CC=NC=C4)C(=O)C(=O)C5=CC=CC=C5.OS(=O)(=O)O