Freund's Incomplete Adjuvant 50mL (C08-0505-314)

Product is a mixture containing mineral oil and Arlacel A. Components are thoroughly mixed in controlled proportions and autoclaved prior to being vialed. If Freud's adjuvant contains killed Mycobacterium tuberculosis, it is known as Complete Freund's Adjuvant. Without the bacteria, it is Incomplete Freund's Adjuvant. Freund's Adjuvant is designed to provide continuous release of antigens necessary for stimulating a strong, persistent immune response. The main disadvantage of Freund's Adjuvant is that it can cause granulomas, inflammation at the inoculation site and lesions. The mycobacteria in Complete Freund's attracts macrophages and other cells to the injection site which enhances the immune response. For this reason, the Complete Freund's Adjuvant is used for the initial injections. To minimize side-effects, Incomplete Freund's Adjuvant is used for the boosts. Freund's Adjuvant is one of the most commonly used adjuvants in research. It is used as a water-in-oil emulsion. It is prepared from non-metabolizable oils (paraffin oil and mannide monooleate). If it also contains killed Mycobacterium tuberculosis, it is known as Complete Freund's Adjuvant. Without the bacteria, it is Incomplete Freund's Adjuvant.