FSCPX is a potent and selective irreversible antagonist of A 1 adenosine receptor (A 1 AR) , with low nanomolar potency for binding to the A 1 AR. FSCPX could modify the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atriumIn VitroFSCPX irreversibly blocks the binding of [ 3 H]-8-cyclopentyl-1,3dipropylxanthine ([ 3 H]DPCPX), with an IC 50 of 11.8±3.2 nM in DDT 1 MF2 cells. FSCPX (20 μM; 48 h) attenuates protection from necrosis and apoptosis in A1AR-overexpressing LLC-PK1 cells. FSCPX (2-20 μM; 48 h) reverses the upregulation of HSP27 mRNA and protein in A1AR-overexpressing LLC-PK1 cells without an effect on the mRNA or protein for HSP70. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:A1AR. Specification: 0.99 Molecular Formula: C23H27FN4O6S Molecular Weight: 506.55 PubChem CID: 133012 Isomeric SMILES: CCCN1C(=O)C2=C(N=C(N2)C3CCCC3)N(C1=O)CCCOC(=O)C4=CC=C(C=C4)S(=O)(=O)F
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- F651495-1mg
- CAS:
- 156547-56-7
- Product Size:
- 1mg
