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furosemide (c15-1247-516)

Furosemide (C15-1247-516)

Sigma-Aldrich

Catalog No.
C15-1247-516
Manufacturer No.
F4381-5G
Manufacturer Name
Sigma-Aldrich
Quantity
5
Unit of Measure
GR
Price: $418.78
List Price: $465.31

Furosemide is a an ototoxic high-ceiling diuretic. Application Furosemide has been used: to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice to study its effect on intracranial pressure

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General description

Furosemide is a an ototoxic high-ceiling diuretic.

Application

Furosemide has been used:

  • to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
  • to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
  • as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

Biochem/physiol Actions

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.

Furosemide can block the Na+/K+/2Cl- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.

Inhibits ion co-transport in the kidney.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

UPC:
51191549
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
F4381-5G


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