G-CSF, Mouse, 10ug (C08-0302-274)

G-CSF, murine (mouse): Granulocyte colony stimulating factor (G-CSF) is a pleiotropic cytokine. It is mainly produced by monocytes and macrophages upon activation by endotoxin, TNF-α and IFN-γ. Besides, many other cell types can secret this protein after LPS, IL-1 or TNF-α activation, which are fibroblasts, endothelial cells, astrocytes, and bone marrow stromal cells. Various carcinoma cell lines and myeloblastic leukemia cells can express G-CSF constitutively. G-CSF is cytokine that acts in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes, and the monocytes-macrophages. In addition, it may function in some adhesion or recognition events at the cell surface. The murine G­CSF cDNA encodes a 208 amino acid (a.a.) residue precursor protein containing a 30 a.a. residue signal peptide that is proteolytically cleaved to generate the 178 a.a. residue mature protein. Murine G-CSF is 73 % identical at the amino acid level to human G-CSF and the two proteins show species cross-reactivity., UnitProt ID: P09920