InformationG150 G150 is a potent and highly selective human cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 10.2 nM.Targetsh-cGAS (Cell-free assay) 10.2 nMIn vitroThe most potent h-cGAS-specific derivative with 2-amino pyridine (G150) shows inhibitory activity in THP1 cells and primary human macrophages while a complete absence of off-target effect on a diverse range of sensors. G150 also shows no substantial cellular toxicity.Cell Research(from reference)Cell lines：THP1 cells, primary macrophage cells Concentrations：10 μM and 5 μM Incubation Time：1 h. Specification: 0.98 Molecular Formula: C18H16Cl2N4O2 Molecular Weight: 391.25 PubChem CID: 138393372 Isomeric SMILES: C1CN(CC2=C1NC3=C2C(=CC(=C3Cl)Cl)C4=CN=C(C=C4)N)C(=O)CO
- UPC:
- 12352208
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G414285-10mg
- CAS:
- 2369751-30-2
- Product Size:
- 10mg
