General description
A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC50 = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.
A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC50 = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.
Biochem/physiol Actions
Primary Target
Galectin-1
Reversible: yes
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Sequence
SVQMKNva-[DBF]-IIVKLNA
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Dings, R.P., et al, 2013, J. Pharm. Exp. Ther.344, 589.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 1654.05. Empirical Formula: C83H132N18O17. Assay: ≥. 98% (HPLC). Quality Level: 100. form: powder. potency: 3 . μ. M IC50. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, protect from light. color: white. solubility: DMSO: 10 . mg/mL. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51131610
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 5058230001
