G-SECRETASE INHIBITOR IV 1PC X 1MG (C15-1305-817)

General description

A cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβ_x-40 (ED₅₀ = 2.6 µM) and Aβ_x-42 (ED₅₀ = 2.7 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.

A cell-permeable, reversible inhibitor of γ-secretase. Inhibits the release of Aβ_x-40 (ED₅₀ = 2.6 µM) and Aβ_x-42 (ED₅₀ = 2.7 µM) in HEK293 cells stably transfected with Amyloid Precursor Protein Swedish mutants.

Biochem/physiol Actions

Cell permeable: yes

ED50 = 2.6 µM for Aβx-40

Primary Target
Aβ_x-40

Product does not compete with ATP.

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

2-Naphthoyl-Val-Phe-CHO

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Green, K.N., et al. 2002. J. Physiol.541.3, 1013.
Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA96, 11049.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 402.49. Empirical Formula: C₂₅H₂₆N₂O₃. Quality Level: 100. Assay: ≥. 95% (HPLC). form: lyophilized solid. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, protect from light. color: white. solubility: DMSO: 10 . mg/mL. shipped in: ambient. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.