Ganglioside GM3 sodium salt

Ganglioside GM3 sodium salt is the major ganglioside of the extra-nervous system. Inhibits growth of epidermal cells. GM3 is known as the main extraneuronal ganglioside. Ganglioside GM3 sodium salt is useful as a substrate for sialidase, after this treatment yields the corresponding lactosylceramide. Also known as the co-receptor of cell growth factor (EGF and FGF). Antibodies to GM3 inhibit 3T3 and NIL cell growth.product description：Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GM3 is the most abundant ganglioside in mammals. It is involved in several tumor processes by interacting with receptors. It inhibits epidermal cell growth and blocks insulin receptor activity. Exogenous GM3 ganglioside inhibits atherosclerosis. Specification: >98% Molecular Formula: C59H107N2NaO21 Molecular Weight: 1203.47 PubChem CID: 71527022 Isomeric SMILES: CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O[C@@]3(C[C@@H]([C@H]([C@@H](O3)[C@@H]([C@@H](CO)O)O)NC(=O)C)O)C(=O)[O-])O)O)O)[C@@H](/C=C/CCCCCCCCCCCCC)O.[Na+] Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/G329630-SCI_d7b865c75dd5e2c0382bc8b3f45c7693.pdf