Application
Gap19 trifluoroacetate salt has been used to inhibit Ca2+/calmodulin (CaM) gating response of connexin 43 (Cx43) gap junctions.
Biochem/physiol Actions
Gap19, nonapeptide from the cytoplasmic loop of Connexin-43, is a selective blocker of connexin 43 (Cx43) hemichannel that does not block GJ or Cx40/Panx-1 channels in cardiomyocytes and astrocytes. Gap19 prevents Cx43 hemichannel opening and protect against myocardial ischemia/reperfusion injury.
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- UPC:
- 51263311
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- SML1426-1MG
- CAS:
- 1507930-57-5
- Temperature Control Device:
- Yes