General description
A potent inhibitor of dopamine active transporter (DAT, Ki = 1 nM, IC50 = 40 and 51 nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models.
Biochem/physiol Actions
Primary Target
DAT
Warning
Toxicity: Standard Handling (A)
Preparation Note
Slight warming is required for complete solubilization.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Young, J. et al. 2010. Psychopharm.208, 443.
Hewitt, K., et al. 2009. Neuropharm.57, 678.
Prisinzano, T. et al. 2002. J. Med. Chem.45, 4371.
Andersen, P., et al. 1989. Eur. J. Pharmacol.166, 493.
Heikkila, R., et al. 1984. Eur. J. Pharmacol.103, 142.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51332205
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 5057320001
- CAS:
- 67469-78-7
