GDC-0623-5 mg

Catalog No.: C08-0327-417
Mfr. No.: 19479-5 EA1
Mfr. Name: Cayman Chemical Company
Qty/UOM: 1
UOM: EA

Price: $308.51

List Price: $342.79

GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki = 0.13 nM in the presence of ATP).

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Description
Specifications

GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki = 0.13 nM in the presence of ATP). It inhibits the proliferation of A375 BRAF(V600E) and HCT116 KRAS(G13D)-mutant cancer cell lines with EC₅₀ values of 7 and 42 nM, respectively. GDC-0623 inhibits ERK and BIM phosphorylation resulting in upregulation and stabilization of pro-apoptotic BIM protein in KRAS mutant and wild-type HCT116 cells and in KRAS mutant GW620 cells.

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UPC:: 12352200
Condition:: New
Availability:: 3 Days
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: 19479-5
Model Number:: C814G71
Temperature Control Device:: Yes

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