General description
Gentamicin Sulfate, consisting of sulfate salts, is a medication derived from antibiotic substances produced during the growth of Micromonospora purpurea bacterium.
Application
Gentamicin sulfate USP reference standard intended for use in specified quality tests and assays.
Also used to prepare system suitability and standard solution for identification, and specific tests according to the given below monographs of United States Pharmacopeia (USP):
- Gentamicin Sulfate
- Gentamicin Injection
- Gentamicin Sulfate and Betamethasone Valerate Ointment
Biochem/physiol Actions
Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.
Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.
Caution
Sterile solutions should be stored at 2-8°C. Solutions have also been shown to be stable at room temperature and in boiling aqueous buffers of pH 2-142.
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. ​
Other Notes
This product is part of the USP Biologics program
USP issued SDS can be found here.
Legal Information
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
- UPC:
- 51281651
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 1289003-200MG