Gilvocarcin V is the major analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp. Gilvocarcin V contains a vinyl group in the 8-position and is the most potent analogue of the complex. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. The metabolite displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research on the gilvocarcins suggests that they act as photoactivated crosslinkers of DNA to histones. Gilvocarcin V has also been shown to be cytotoxic against Gram-positive bacteria. Mediates a unique cross-linking reaction between DNA and histidine H3. And is shown to be weakly active against Gram-negative bacteria, fungi and tumors. Also an antineoplastic and a photosensitizing compound. Specification: >95% Molecular Formula: C27H26O9 Molecular Weight: 494.49 PubChem CID: 334288 Isomeric SMILES: CC(C1C(C(C(O1)C2=C3C(=C(C=C2)O)C(=CC4=C3OC(=O)C5=C4C(=CC(=C5)C=C)OC)OC)O)O)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/G329586-SCI_4cb575058e1c8f153687952e6eda8877.pdf
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G329586-250μg
- CAS:
- 77879-90-4
- Product Size:
- 250μg
- Hazard Statement Codes:
- H302+H312+H332
- Precautionary Statement Codes:
- P261:P264:P270:P271:P280
