Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activityIn VitroGiredestrant (GDC-9545) 是一种新型 ER 拮抗剂，结合了理想的机制和临床前 DMPK 属性。Giredestrant 的高效体内功效可能是由于其具有高 ER 结合力、ER 信号传导的完全抑制和改善的 DMPK 特征。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:ER. Specification: ≥98% Molecular Formula: C27H31F5N4O Molecular Weight: 522.55 PubChem CID: 121410806 Isomeric SMILES: C[C@@H]1CC2=C([C@H](N1CC(CO)(F)F)C3=C(C=C(C=C3F)NC4CN(C4)CCCF)F)NC5=CC=CC=C25
- UPC:
- 12352205
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G651429-5mg
- CAS:
- 1953133-47-5
- Product Size:
- 5mg
