Amino Acid Sequence
His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
General description
Glucagon is a peptide hormone of 29 amino acids secreted by alpha cells in the pancreas. Its release is controlled by hypothalamus when glucose levels in the blood decreases. The C-terminal region of glucagon is crucial for receptor binding.
Application
Glucagon has been used:
- in the stimulation of human primary hepatocytes for cyclic adenosine monophosphate (cAMP) production
- for measuring glucagon response in mice
- to induce gluconeogenic stimuli in primary hepatocytes
Biochem/physiol Actions
Glucagon functions to elevate glucose by activating GCGR in liver mediating the glucose circulation in blood. The hyperglucagonemia elevated levels of glucagon is observed in diabetes and in nonalcoholic fatty liver disease, post gastric bypass surgery and glucagon based tumors.
Components
H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl
Other Notes
This product is a chemically synthesized glucagon qualified for use in cell culture applications.
Physical form
powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw
- UPC:
- 51183602
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G2044-5MG
