General description
Glucose 6-phosphate dehydrogenase (G-6-P-DH) is a key regulatory enzyme in the first step of the pentose phosphate pathway. G-6-P-DH is a glycoprotein with a molecular mass of 128 kDa (gel filtration).G6PD is a dimer and consists of a single active site at each subunit.
Research area: Cell Signaling
Application
Glucose-6-phosphate dehydrogenase has been used:
- to test ketose reductase activity in developing maize endosperm.
- to determine the levels of mannose in coronary heart disease patient-derived serum
- to study its activity on extracellular polymeric substance (EPS) extract to determine cell lysis through sonication
- to determine the glucose uptake in cultured human muscle satellite cells
Biochem/physiol Actions
G6PD provides all cells with reducing power as nicotinamide adenine dinucleotide phosphate (NADPH) which enables the cells to balance oxidative stress. Mutations in the G6PD gene are associated with X-linked G6PD deficiency, a hereditary genetic defect such as neonatal jaundice and acute hemolytic anemia.
Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconolacetone as the first step in the pentose phosphate pathway.
Unit Definition
One unit will oxidize 1.0 μmole of
Physical form
Suspension in 3.2 M (NH4)2SO4 containing 50 mM Tris and 1 mM MgCl2, pH 7.5
- UPC:
- 51422119
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G8404-10KU