Biochem/physiol Actions Glutipyran is a broad-spectrum potent and selective glucose transporter (GLUT) inhibitor that targets both GLUT1 and GLUT3. Glutipyran inhibits glycolytic activity and cell growth in PANC-1 cells (IC50 = 1.
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Glutipyran is a broad-spectrum potent and selective glucose transporter (GLUT) inhibitor that targets both GLUT1 and GLUT3. Glutipyran inhibits glycolytic activity and cell growth in PANC-1 cells (IC50 = 1.9 µM). It exhibits antitumor activity (12.5 mg/kg, i.v.) once daily in MIA PaCa-2 xenograft mouse model.
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