GLYCYCOUMARIN (C005B-314006)

General description

Glycycoumarin, a major bioactive coumarin, is an aromatic ether and a member of resorcinols. This bioactive natural product is commonly derived from Glycyrrhiza Sp. (G. glabra, G. uralensis and G. radix) plants. Existing research suggests that this plant-derived metabolite exerts various biological activities, including anti-spasmodic, hepatoprotective, anticancer, neuroprotective, antioxidant and anti-inflammatory activities.

Application

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem/physiol Actions

According to the existing research, Glycycoumarin serves as an estrogen agonist while also exhibiting moderate inhibitory effects on enzymes CYP1A2 and CYP2B6. Notably, Glycycoumarin demonstrates potent anti-hepatitis C virus (HCV) activity, with an IC(50) value of 8.8 µg/mL. Furthermore, it effectively inhibits smooth muscle contraction induced by various stimuli by targeting PDEs, especially isozyme 3, which leads to the accumulation of intracellular cAMP, a vital component of cellular signaling. Additionally, Glycycoumarin acts as a potent antispasmodic through the inhibition of phosphodiesterase 3, further underscoring its significance in modulating cellular responses and health. Moreover, it plays a crucial role in inhibiting hepatocyte lipoapoptosis by activating autophagy and inhibiting the ER stress/GSK-3-mediated mitochondrial pathway, showcasing its importance in cellular function.

Glycycoumarin exhibits antispasmodic activity and has a role as an antispasmodic drug and a plant metabolite. It has been demostrated to be a novel active component of licorice against non-alcoholic fatty liver disease (NAFLD).

Features and Benefits

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques