GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7 , with an IC 50 of 3 nM.In VitroGNE-131 (Compound 13) shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 with an IC 50 of 0.003±0.001 μM. GNE-131 shows excellent potency, good in vitro metabolic stability. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoGNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Na v 1.7 3 nM (IC 50 ). Specifications and Purity: 98%. Molecular Formula: C23H30N4O3S. Molecular Weight: 442.57. PubChem CID: 91666633. Isomeric SMILES: C1CC1C2=CN3C(=NN=C3NS(=O)(=O)C4CC4)C=C2OCC56CC7CC(C5)CC(C7)C6.
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G646736-25mg
- CAS:
- 1629063-81-5
- Product Size:
- 25mg
