GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC 50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC 50 of 30 nM for IL-17 PBMCIn VivoGNE-6468 (compound 28) displays high predicted clearance values in human and rodent hepatocytes (CL hep = 17 and 42 mL/min/kg, respectively) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:ROR-γ 2 nM (EC 50 ). Specification: 0.98 Molecular Formula: C23H16ClN3O4 Molecular Weight: 433.84 PubChem CID: 117964975 Isomeric SMILES: C1CC1C2=C(C(=CC=C2)Cl)C(=O)C3=NC(=C4N3C=CC=N4)C5=CC(=C(C=C5)C(=O)O)O
- UPC:
- 12352205
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G651767-50mg
- CAS:
- 1677668-27-7
- Product Size:
- 50mg
