Gold Nanoshells (C09-0902-804)

Product description：Lipoic Acid contains both a carboxyl group and a dithiol group. The dithiol group strongly binds to the metal nanoparticle surface after reduction while the carboxylic acid group is available for further chemical derivatization. The acid group also provides a highly negatively charged surface at appropriately high pH.Carboxyl surfaces can be used to covalently bind molecules with free amines (e.g. antibodies) to the surface of the particles. An amide bond between the acid surface and the free amine is formed using EDC / NHS chemistry.At nanoComposix we use two different molecules to provide a surface with chemically accessible carboxylic acids. One is lipoic acid and the other is the lipoic acid derivative, lipoic-dPEG12-COOH, which is similar to lipoic acid but contains a PEG spacer between the thiol and carboxylic acid functional groups.For BioReady gold nanoparticles with diameters less than 100 nm, the lipoic-dPEG12-acid is used. For larger diameter BioReady nanoparticles (e.g. 150 nm gold nanoshells), lipoic acid is used.Peak Wavelength(> 90% peak absorbance)：980 nmSilica Core Diameter：200 nm ± 10 nmGold Shell Thickness：20 nm ± 7 nmHydrodynamic diameter (DLS): TEM diameter plus to 30 nmZeta potential: –25 to –70 mVpH of solution: 5.0 to 7.5Particle surface: lipoic acidSolvent: .02 mM potassium carbonate. Specification: λₘₐₓ, 980nm, NanoXact, 1mg/mL in water, Carboxyl (Lipoic Acid)