GPR40 agonist 6 (Compound 7a) is a potent and selective free fatty acid receptor 1 ( FFAR1 or GPR40 ) agonist with an EC 50 of 0.058 μMIn VitroGPR40 agonist 6 (Compound 7a) shows a very favorable ADME profile, and shows no significant inhibition of the principal cytochrome P450 isoforms (1A2, 2C9, 2C19, 2D6 and 3A4) at 5 µM. ADME profile for GPR40 agonist 6 (Compound 7a)GPR40 agonist 6 (Compound 7a) Plasma protein binding (human) a 98.6% Aqueous solubility (PBS, pH 7.4) b 404 µM Microsomal stability (mouse, t1/2) c 434 min A-B permeability (Caco-2, cm•s -1 ) d 15.2 • 10 -6 a Each value is an average of n = 4, measured at c = 1 µM. b Each value is an average of n = 2. c Each value is an average of n = 5, measured at c = 2 µM. d Each value is an average of n = 2, measured at c = 10 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:EC 50 : 0.058 μM (GPR40). Specification: 0.99 Molecular Formula: C20H19NO4 Molecular Weight: 337.37
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G650127-5mg
- CAS:
- 1798751-25-3
- Product Size:
- 5mg
