Granzyme B Inhibitor I - Calbiochem (C15-1303-057)

General description

A weak inhibitor of the human and murine granzyme B. Also inhibits the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID₅₀ = 300 nM).

A weak inhibitor of the human and murine serine protease granzyme B. Also inhibits the apoptosis related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID₅₀ = 300 nM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Granzyme B

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 300 nM against the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Ala-Ala-Asp-CH₂Cl

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gong, B., et al. 1999. Cell Growth Different. 10, 491.
Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
Odake, S., et al. 1991. Biochemistry30, 2217.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 441.86. Empirical Formula: C₁₉H₂₄ClN₃O₇. Quality Level: 100. Assay: ≥. 95% (HPLC). form: solid. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, desiccated. color: off-white. solubility: DMSO: 5 . mg/mL. shipped in: ambient. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.