General description
A reversible inhibitor of Granzyme B that also inhibits caspase-8. Granzyme B is a protease involved in the induction of rapid target cell death by cytotoxic lymphocytes.
A reversible inhibitor of granzyme B and caspase-8.
Biochem/physiol Actions
Cell permeable: no
Primary Target
granzyme B
Product does not compete with ATP.
Reversible: yes
Warning
Toxicity: Standard Handling (A)
Sequence
Ac-Ile-Glu-Pro-Asp-CHO
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Harris, J.L., et al. 1998. J. Biol. Chem. 273, 27364.
Thornberry, N.A., et al. 1997. J. Biol. Chem.272, 17907.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 498.53. Empirical Formula: C22H34N4O9. Quality Level: 100. Assay: ≥. 97% (HPLC). form: solid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze. color: white. solubility: DMSO: 5 . mg/mL. shipped in: ambient. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51172445
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 368056-1MG
