General description
A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 0.5 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, selective, and non-ATP competitive inhibitor of GSK-3β (IC50 = 500 nM). Does not affect the activity of PKA even at concentrations as high as 100 µM.
Biochem/physiol Actions
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target IC50: 0.5 µM against GSK-3β
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Other Notes
Conde, S., et al. 2003. J. Med. Chem.46, 4631.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51183800
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 361548-5MG