InformationGSK180736A (GSK180736) GSK180736A (GSK180736), developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to GRK2(G protein-coupled receptor kinase 2) with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1); ≥400-fold selective for GRK2 over both GRK1 and GRK5.TargetsROCK (Cell-free assay); GRK2 (Cell-free assay) 100 nM; 6.6(pIC50)In vitroGSK180736A exhibits a 770 nM IC50 value against GRK2 and 300-fold less potency against GRK5. It is a weak inhibitor of PKA with an IC50 of 30 μM, but highly potent against ROCK1 (IC50 = 100 nM). Specification: 10mM in DMSO Molecular Formula: C19H16FN5O2 Molecular Weight: 365.36 PubChem CID: 11233873 Isomeric SMILES: CC1=C(C(NC(=O)N1)C2=CC=C(C=C2)F)C(=O)NC3=CC4=C(C=C3)NN=C4
- UPC:
- 51183105
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.85 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G426113-1ml
- CAS:
- 817194-38-0
- Product Size:
- 1ml
