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gsk2193874 (c15-1724-581)

GSK2193874 (C005B-312752)

Catalog No.
C005B-312752
Mfr. No.
SML0942-5MG
Mfr. Name
Sigma-Aldrich
Qty/UOM
5
UOM
MG
Price: $283.96
List Price: $315.51

Application GSK2193874 has been used as a transient receptor potential vanilloid 4 (TRPV4) antagonist: to study its effects on GSK101-induced colon contractions in mice to study its effects on murine compact bone-derived osteoblasts(CB-OB)

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Application

GSK2193874 has been used as a transient receptor potential vanilloid 4 (TRPV4) antagonist:

  • to study its effects on GSK101-induced colon contractions in mice
  • to study its effects on murine compact bone-derived osteoblasts(CB-OB)
  • to study its effects on lung injury post-lipopolysaccharide (LPS) in mice

Biochem/physiol Actions

GSK2193874 is a very potent, specific antagonist of TRPV4 ion channels (IC50 = 50 nM). Lung edema caused by high pulmonary venous pressure (PVP) is driven by TRPV4 activity. GSK2193874 blocks TRPV4-mediated calcium influx in cells expressing native and recombinant TRPV4, and inhibits vascular permeability and lung edema in isolated rodent and canine lungs subjected to high PVP. The compound also resolves pulmonary edema in murine myocardial infarction model.

Shipping Information:

Hazmat Fee: $65.00 + applicable shipping charges are added after the order is placed.

More Information: https://cenmed.com/shipping-returns

UPC:
51162627
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
Yes
MPN:
SML0942-5MG
CAS:
1336960-13-4

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