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GSK264220A (C15-1721-643)

Sigma Aldrich

Catalog No.
C15-1721-643
Manufacturer No.
SML2931-5MG
Manufacturer Name
Sigma-Aldrich
Quantity
5
Unit of Measure
MG
Price: $187.93
List Price: $208.81

Biochem/physiol Actions GSK264220A is a potent, active site-targeting, covalent inhibitor against endothelial lipase (EL or LIPG: IC 50 = 130 nM) and lipoprotein lipase (LPL or LIPD: IC 50 = 100 nM). GSK264220A reduces NeuT expression - or CoCl

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Biochem/physiol Actions

GSK264220A is a potent, active site-targeting, covalent inhibitor against endothelial lipase (EL or LIPG; IC50 = 130 nM) and lipoprotein lipase (LPL or LIPD; IC50 = 100 nM). GSK264220A reduces NeuT expression - or CoCl2 treatment-induced intracellular triacylglycerol & lipid droplets (TAG & LD) increase in MCF-7 (16 & 32 nM) and suppresses LPL-depenent melanoma survival (by ~50% at 18.75 μM; WM852, WM1361). When applied in mice in vivo (30 mg/kg ip.), GSK264220A21 enhances lipid nanoparticles-mediated siRNAs delivery & gene-silencing efficacy.

UPC:
51292105
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
SML2931-5MG
Product Size:
5/MG
CAS:
685506-42-7

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